NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 2-alpha, 3-alpha, 19-beta, 23-beta-tetrahydroxyurs-12-en-28-oic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581-A2780----A2780 cells exposed to compound showed a dose-dependent concomitant increase in the level of Bax and the Bax/Bcl-2 ratio, compared with the control cells21695177
BAXBCL2-associated X protein581-HepG2----HepG2 cells exposed to compound showed a dose-dependent concomitant increase in the level of Bax and the Bax/Bcl-2 ratio, compared with the control cells21695177
BCL2B-cell CLL/lymphoma 2596-A2780----A2780 cells exposed to compound showed a dose-dependent reduction in the level of Bcl-2 protein21695177
BCL2B-cell CLL/lymphoma 2596-HepG2----HepG2 cells exposed to compound showed a dose-dependent reduction in the level of Bcl-2 protein21695177
CASP3caspase 3, apoptosis-related cysteine peptidase836-A2780----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in A2780. The expression of procaspase-3 was clearly decreased in a dose-dependent manner.21695177
CASP3caspase 3, apoptosis-related cysteine peptidase836-HepG2----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in HepG2. The expression of procaspase-3 was clearly decreased in a dose-dependent manner.21695177
CASP8caspase 8, apoptosis-related cysteine peptidase841-A2780----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in A2780. The expression of procaspase-8 was clearly decreased in a dose-dependent manner.21695177
CASP8caspase 8, apoptosis-related cysteine peptidase841-HepG2----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in HepG2. The expression of procaspase-8 was clearly decreased in a dose-dependent manner.21695177
CASP9caspase 9, apoptosis-related cysteine peptidase842-A2780----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in A2780. The expression of procaspase-9 was clearly decreased in a dose-dependent manner.21695177
CASP9caspase 9, apoptosis-related cysteine peptidase842-HepG2----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in HepG2. The expression of procaspase-9 was clearly decreased in a dose-dependent manner.21695177
CCND1cyclin D1595-A2780----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in A2780. The expression of Cyclin-D1 was slightly decreased in a dose-dependent manner.21695177
CCND1cyclin D1595-HepG2----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in HepG2. The expression of Cyclin-D1 was slightly decreased in a dose-dependent manner.21695177
CDK1cyclin-dependent kinase 1983-A2780----Tested compoud induced changes in the expression of cell cycle regulatory proteins, and the expression level of Cdc2 were decreased clearly21695177
CDK1cyclin-dependent kinase 1983-HepG2----Tested compoud induced changes in the expression of cell cycle regulatory proteins, and the expression level of Cdc2 were decreased clearly21695177
CYCScytochrome c54205-A2780----Cytosolic release of Cytochrome c from mitochondrionwas detected in A2780 cells21695177
CYCScytochrome c54205-HepG2----Cytosolic release of Cytochrome c from mitochondrionwas detected in HepG2 cells21695177
MYCv-myc myelocytomatosis viral oncogene4609-A2780----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in A2780. The expression of c-Myc was clearly decreased in a dose-dependent manner.21695177
MYCv-myc myelocytomatosis viral oncogene4609-HepG2----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in HepG2. The expression of c-Myc was clearly decreased in a dose-dependent manner.21695177
PARP1poly (ADP-ribose) polymerase 1142-A2780----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in A2780. The PARP cleavage was induced by treatent of this compound.21695177
PARP1poly (ADP-ribose) polymerase 1142-HepG2----Consistent with its effect on apoptosis,THA induced changes in the expression of apoptosis related proteins in HepG2. The PARP cleavage was induced by treatent of this compound.21695177

 






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