NPACT

NPACT is a database of anticancer natural compounds present in plants. Database currently contains 1574 compounds and the relevant information has been generated from text mining of around 762 published articles. It currently provides details for anticancer activity against 353 cancer cell lines which corresponds to 5214 in-vitro compound-cell line interactions. For each of these interactions we provide experimentally determined inhibitory values. NPACT also provides information on in-vivo experiments as well as protein targets that have been demonstrated in cancer cell lines to be inhibited by these naturally occuring compounds.

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SEARCH
In search option, user can search by two methods:- Simple search or Advance search
1.Simple Search
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2.Advance Search
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BROWSE
User can browse compounds by 5 ways: Alphabetical order, Class name, Cancerous Cell Line, Type of cancer and name of suppliers.
1. Browse compound Alphabetically
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2. Browse compound by Cancer Type
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3. Browse compound by Cell line
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4. Browse compound by Class
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5. Browse compound by Target
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6. Browse compound by Suppliers
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ACTIVITY
In NPACT, we have provided in-vitro as well as in-vivo anticancer activities of compounds. We can go to these activities by a single click.
1. In-vitro anticancer activity
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2. In-vivo anticancer activity
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3. Target Information
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SIMILARITY SEARCH TOOL
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STRUCTURE
1. 2D & 3D Structure
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2. Download Molecule
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OTHER FEATURES
1. Cross references in other databases
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2. Properties
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3. Filter Description

Filters	Description
Lipinski's rule of five	Mass: <= 500, LogP: <= 5, DonorCount: <= 5 And AcceptorCount: <= 10
Ghose Filter	Mass: (>= 160&<= 480), AtomCount: (>= 20&<= 70), LogP: (>=-0.4&<= 5.6) And Refractivity: (>= 40&<= 130)
Muegge Filter	Mass: (>= 200&<= 600), RingCount: <= 7, AtomCount: >= 5, RotatableBondCount: <= 15, DonorCount: <= 5, AcceptorCount: <= 10, LogP: (>= -2) & <= 5) And PSA: <= 150
Veber Filter	RotatableBondCount: <= 10 And PSA: <= 140

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