NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Xindongnin B

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790HepatomaHep G21.25±0.33 µM---Compound inhibited in a concentration-dependent manner the DNA binding activity of p50.15872117
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790HepatomaHep G21.25±0.33 µM---The effects of Xdn-B isolated from I. rubescens and KA, a known NF-kappaB inhibitor, on NF-kappaB activation were investigated using HepG2 cell lines; Compounds inhibited the TNF-alpha -and PMA-induced expression of NF-kappaB reporter gene in a concentration-dependent manner.15872117

 






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