NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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Compound: tylophoridicine C

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Hepatoma

Hep G2

600±173 nM

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The inhibitory effects of compound against NF-kappaB, CRE-, and AP-1-mediated transcription wad shown. The results indicate that this compounds preferentially inhibits NF-kappaB-mediated transcription, as the IC50 values in terms of NF-kappaB inhibition are significantly lower.

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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.