NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Saikosaponin A

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ATF2activating transcription factor 21386HepatomaHep G2----Phosphorylation of one of the down-stream transcriptional factors of MAPK cascade, ATF2,was 3.2- and 2.0-fold induced by TPA and Saikosaponin A, respectively.12592382
FOSFBJ murine osteosarcoma viral oncogene homolog2353HepatomaHep G2----Expressions of proto-oncogene c-fos was induced by TPA and Saikosaponin a during 30min to 6 h of treatment.12592382
JUNjun proto-oncogene3725HepatomaHep G2----Expressions of proto-oncogene c-jun was induced by TPA and Saikosaponin a during 30min to 6 h of treatment.12592382
JUNBjun B proto-oncogene3726HepatomaHep G2----Expressions of proto-oncogene junB was induced by TPA and Saikosaponin a during 30min to 6 h of treatment.12592382
MAPK1mitogen-activated protein kinase 15594HepatomaHep G2----Phosphorylation of ERK is dramatically induced (11.6-fold ) by TPA during 15min to 1 h and significantly induced (2.5-fold) by Saikosaponin A at 30min.12592382

 






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