NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: longilactone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast adenocarcinomaMCF-7----Enzyme assay indicated that the caspase-3 activity in MCF-7 cells treated by longilactone was increased significantly in a time-dependent manner, but the caspase-9 was not affected.Research In Pharmaceutical Biotechnology.,3(1).,2011
CASP7caspase 7, apoptosis-related cysteine peptidase840Breast adenocarcinomaMCF-7----Western blots of several proteins in MCF-7 upon exposure to longilactone at various incubation times and results indicate that longilactone increased the active caspase-7 (20 kDa) in a time-dependent manner.Research In Pharmaceutical Biotechnology.,3(1).,2011
CASP8caspase 8, apoptosis-related cysteine peptidase841Breast adenocarcinomaMCF-7----Western blots of several proteins in MCF-7 upon exposure to longilactone at various incubation times and results indicate that longilactone increased the procaspase-8 (55 kDa), active caspase-8 (29 kDa), in a time-dependent manner.Research In Pharmaceutical Biotechnology.,3(1).,2011
PARP1poly (ADP-ribose) polymerase 1142Breast adenocarcinomaMCF-7----Western blots of several proteins in MCF-7 upon exposure to longilactone at various incubation times and results indicate that longilactone increased the cleaved subunit of poly (ADP-ribose) polymerase (PARP 89 kDa) in a time-dependent manner.Research In Pharmaceutical Biotechnology.,3(1).,2011

 






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