NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: liriodenine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CCNB1cyclin B1891Lung adenocarcinomaA549----The kinase activity of the cyclin B1/CDK1 complex was potently inhibited. It is possible that liriodenine may affect the phosphorylation and dephosphorylation of this protein complex to induce G2/M arrest.15473647
NOS2nitric oxide synthase 2, inducible4843HepatomaHep G2----Intracellular NO level were markedly increased in Hep G2 cells after liriodenine treatment.15833387
NOS2nitric oxide synthase 2, inducible4843HepatomaHep G2----The iNOS expression was markedly increased in Hep G2 cells after liriodenine treatment.15833387
PARP1poly (ADP-ribose) polymerase 1142Lung adenocarcinomaA549----According to results, liriodenine could effectively trigger caspase activation and PARP degradation and induce apoptosis in A549 lung cancer cells.15473647
TP53tumor protein p537157HepatomaHep G2----The p53 level was markedly increased in Hep G2 cells after liriodenine treatment.15833387

 






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