Compound: Indole-3-carbinol

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

BAX

BCL2-associated X protein

581

Prostate Cancer

PC-3

Induction of G1 cell cycle arrest was also observed in PC-3 cells treated with Indole-3-carbinol (I3C), which may be due to the observed effects of I3C in the up-regulation of p21WAF1 and p27Kip1 CDK inhibitors, followed by their association with cyclin D1 and E and down-regulation of CDK6 protein kinase levels and activity. In addition, I3C inhibited the hyperpohosphorylation of the Retino-blastoma (Rb) protein in PC-3 cells. and poly(ADP-ribose) polymersae (PARP) cleavage. We also found an up-regulation of Bax, and down-regulation of Bcl-2 in I3C-treated cells. These effects may also be mediated by the down-regulation of NF-kappaB observed in I3C treated PC-3 cells.

11420705

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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