NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Indole-3-carbinol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Prostate CancerPC-3----Induction of G1 cell cycle arrest was also observed in PC-3 cells treated with Indole-3-carbinol (I3C), which may be due to the observed effects of I3C in the up-regulation of p21WAF1 and p27Kip1 CDK inhibitors, followed by their association with cyclin D1 and E and down-regulation of CDK6 protein kinase levels and activity. In addition, I3C inhibited the hyperpohosphorylation of the Retino-blastoma (Rb) protein in PC-3 cells. and poly(ADP-ribose) polymersae (PARP) cleavage. We also found an up-regulation of Bax, and down-regulation of Bcl-2 in I3C-treated cells. These effects may also be mediated by the down-regulation of NF-kappaB observed in I3C treated PC-3 cells.11420705
BCL2B-cell CLL/lymphoma 2596Prostate CancerPC-3----Induction of G1 cell cycle arrest was also observed in PC-3 cells treated with Indole-3-carbinol (I3C), which may be due to the observed effects of I3C in the up-regulation of p21WAF1 and p27Kip1 CDK inhibitors, followed by their association with cyclin D1 and E and down-regulation of CDK6 protein kinase levels and activity. In addition, I3C inhibited the hyperpohosphorylation of the Retino-blastoma (Rb) protein in PC-3 cells. and poly(ADP-ribose) polymersae (PARP) cleavage. We also found an up-regulation of Bax, and down-regulation of Bcl-2 in I3C-treated cells. These effects may also be mediated by the down-regulation of NF-kappaB observed in I3C treated PC-3 cells.11420705
CDK6cyclin-dependent kinase 61021Prostate CancerPC-3----Induction of G1 cell cycle arrest was also observed in PC-3 cells treated with Indole-3-carbinol (I3C), which may be due to the observed effects of I3C in the up-regulation of p21WAF1 and p27Kip1 CDK inhibitors, followed by their association with cyclin D1 and E and down-regulation of CDK6 protein kinase levels and activity. In addition, I3C inhibited the hyperpohosphorylation of the Retino-blastoma (Rb) protein in PC-3 cells. and poly(ADP-ribose) polymersae (PARP) cleavage. We also found an up-regulation of Bax, and down-regulation of Bcl-2 in I3C-treated cells. These effects may also be mediated by the down-regulation of NF-kappaB observed in I3C treated PC-3 cells.11420705
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Prostate CancerPC-3----Induction of G1 cell cycle arrest was also observed in PC-3 cells treated with Indole-3-carbinol (I3C), which may be due to the observed effects of I3C in the up-regulation of p21WAF1 and p27Kip1 CDK inhibitors, followed by their association with cyclin D1 and E and down-regulation of CDK6 protein kinase levels and activity. In addition, I3C inhibited the hyperpohosphorylation of the Retino-blastoma (Rb) protein in PC-3 cells. and poly(ADP-ribose) polymersae (PARP) cleavage. We also found an up-regulation of Bax, and down-regulation of Bcl-2 in I3C-treated cells. These effects may also be mediated by the down-regulation of NF-kappaB observed in I3C treated PC-3 cells.11420705
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)1027Prostate CancerPC-3----Induction of G1 cell cycle arrest was also observed in PC-3 cells treated with Indole-3-carbinol (I3C) , which may be due to the observed effects of I3C in the up-regulation of p21WAF1 and p27Kip1 CDK inhibitors, followed by their association with cyclin D1 and E and down-regulation of CDK6 protein kinase levels and activity. In addition, I3C inhibited the hyperpohosphorylation of the Retino-blastoma (Rb) protein in PC-3 cells. and poly(ADP-ribose) polymersae (PARP) cleavage. We also found an up-regulation of Bax, and down-regulation of Bcl-2 in I3C-treated cells. These effects may also be mediated by the down-regulation of NF-kappaB observed in I3C treated PC-3 cells.11420705
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerPC-3----Induction of G1 cell cycle arrest was also observed in PC-3 cells treated with Indole-3-carbinol (I3C), which may be due to the observed effects of I3C in the up-regulation of p21WAF1 and p27Kip1 CDK inhibitors, followed by their association with cyclin D1 and E and down-regulation of CDK6 protein kinase levels and activity. In addition, I3C inhibited the hyperpohosphorylation of the Retino-blastoma (Rb) protein in PC-3 cells. and poly(ADP-ribose) polymersae (PARP) cleavage. We also found an up-regulation of Bax, and down-regulation of Bcl-2 in I3C-treated cells. These effects may also be mediated by the down-regulation of NF-kappaB observed in I3C treated PC-3 cells.11420705
PARP1poly (ADP-ribose) polymerase 1142Prostate CancerPC-3----The induction of apoptosis was pronounced at 48 h of treatment, and appears to be correlated with cell growth inhibition. In addition , PARP cleavage analys is showed that the full size PARP (116 KD) protein was cleaved to yield an 85 kD a fragment after treatment with Indole-3-carbinol (I3C) for 48 h in PC-3 cells providing further evidence for the induction of apoptosis in I3C treated PC-3 cells.11420705
RB1retinoblastoma 15925Prostate CancerPC-3----Induction of G1 cell cycle arrest was also observed in PC-3 cells treated with Indole-3-carbinol (I3C), which may be due to the observed effects of Indole-3-carbinol (I3C) in the up-regulation of p21WAF1 and p27Kip1 CDK inhibitors, followed by their association with cyclin D1 and E and down-regulation of CDK6 protein kinase levels and activity. In addition, Indole-3-carbinol (I3C) inhibited the hyperpohosphorylation of the Retino-blastoma (Rb) protein in PC-3 cells. and poly(ADP-ribose) polymersae (PARP) cleavage. We also found an up-regulation of Bax, and down-regulation of Bcl-2 in Indole-3-carbinol (I3C)-treated cells. These effects may also be mediated by the down-regulation of NF-kappaB observed in Indole-3-carbinol (I3C) treated PC-3 cells.11420705

 






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