NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Eurycomanone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ANXA1annexin A1301Lung adenocarcinomaA549----Treatment with eurycomanone(8 µg/ml)decreased the mRNA levels of annexin 1 by 1.6 folds.21903368
BAXBCL2-associated X protein581HepatomaHep G2----Eurycomanone was cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of Ba.19508737
BCL2B-cell CLL/lymphoma 2596HepatomaHep G2----Eurycomanone was cytotoxic on HepG2 cells by inducing apoptosis through the doown-regulation of Bcl-2.19508737
CYCScytochrome c54205HepatomaHep G2----Eurycomanone triggered cytohrome C in a time dependent manner. The percentage of 74.4% was determined at 24 hours of treatment and 86.1% at 48 hours. At 72 hours, the level of cytochrome C proteins showed a maximal value of 95.5.19508737
ERP29endoplasmic reticulum protein 2910961Lung adenocarcinomaA549----Treatment with eurycomanone also resulted in significant down-regulation of the endoplasmic reticulum luminal protein ERp28 (ERp29 precursor). Treatment with eurycomanone(8 µg/ml)decreased the mRNA levels of Erp28 by 1.9 fold.21903368
HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B13181Lung adenocarcinomaA549----Results from the study suggested that the treatment with eurycomanone down-regulated hnRNP A2/B1.21903368
PHBprohibitin5245Lung adenocarcinomaA549----Prohibitin expression was significantly downregulated at the protein levels but not at the transcriptional level. Treatment with eurycomanone(8 µg/ml)decreased the mRNA levels of prohibitin by 1.3 folds21903368
TP53tumor protein p537157HepatomaHep G2----Eurycomanone was cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53.19508737
TP53tumor protein p537157Lung adenocarcinomaA549----The expression of p53, a tumor suppressor protein that regulate the cell cycle and cell proliferation commonly overexpressed in cancer cells was also found reduced in the eurycomanone-treated cells when compared to the DMSO-treated control21903368

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.