NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Ellipticine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP8caspase 8, apoptosis-related cysteine peptidase841Breast adenocarcinomaMCF-7----Treatment of cells with ellipticine resulted in inhibition of growth, and G2/M phase arrest of the cell cycle. T Ellipticine treatment increased the expression of Fas/APO-1 and its ligands, mFas ligand and sFas ligand, and subsequent activation of caspase-8.15896464
CASP9caspase 9, apoptosis-related cysteine peptidase842Breast adenocarcinomaMCF-7----Treatment of cells with ellipticine resulted in inhibition of growth, and G2/M phase arrest of the cell cycle. A significant increase in activation of caspase-9 was found to occur.15896464
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)1027Breast adenocarcinomaMCF-7----Treatment of cells with ellipticine resulted in inhibition of growth, and G2/M phase arrest of the cell cycle. This effect was associated with a marked increase in the protein expression of KIP1/p27.15896464
FasTNF receptor superfamily, member 7355Breast adenocarcinomaMCF-7----Treatment of cells with ellipticine resulted in inhibition of growth, and G2/M phase arrest of the cell cycle. T Ellipticine treatment increased the expression of Fas/APO-1 and its ligands, mFas ligand and sFas ligand, and subsequent activation of caspase-8.15896464
TP53tumor protein p537157Breast adenocarcinomaMCF-7----Treatment of cells with ellipticine resulted in inhibition of growth, and G2/M phase arrest of the cell cycle. This effect was associated with a marked increase in the protein expression of p53.15896464

 






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