NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Diosgenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Breast AdenocarcinomaAU565----Diosgenin inhibited the phosphorylation of Akt18022396
CASP3caspase 3, apoptosis-related cysteine peptidase836Epidermoid carcinoma of larynxHep-2----At 24 h,caspase activities were enhanced significantly (1.6-fold for caspase-3 versus controls, p<0.01)15225412
CASP3caspase 3, apoptosis-related cysteine peptidase836TumorsM-4-BEU----caspase-3 activity was more markedly induced at the same time (3.4- and 2.2-fold respectively versus controls, p<0.01)15225412
CASP9caspase 9, apoptosis-related cysteine peptidase842Epidermoid carcinoma of larynxHep-2----At 24 h,caspase activities were enhanced significantly (1.2-fold for caspase-9 versus controls, p<0.01)15225412
CASP9caspase 9, apoptosis-related cysteine peptidase842TumorsM-4-BEU----caspase-9 activity was moderately induced at 12 and 24 h [1.3-(p<0.01) and 1.2-fold (p<0.05) at 12 and 24 h respectively versus controls] 15225412
FasTNF receptor superfamily, member 6355Breast AdenocarcinomaAU565----Diosgenin, a plant-derived steroid, was found to be effective in suppressing FAS expression in HER2-overexpressing breast cancer cells. Diosgenin preferentially inhibited proliferation and induced apoptosis in HER2-overexpressing cancer cells.18022396
MAPK8mitogen-activated protein kinase 85599Breast AdenocarcinomaAU565----Diosgenin enhanced phosphorylation of JNK.18022396
MTORmechanistic target of rapamycin (serine/threonine kinase)2475Breast AdenocarcinomaAU565----Diosgenin inhibited the phosphorylation mTOR.18022396
PARP1poly (ADP-ribose) polymerase 1142Epidermoid carcinoma of larynxHep-2----Partial PARP cleavage was observed by treating cells with diosgenin.15225412
PARP1poly (ADP-ribose) polymerase 1142TumorsM-4-BEU----Partial PARP cleavage was observed by treating cells with diosgenin.15225412

 






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