NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Diallyldisulfide

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

caspase 3, apoptosis-related cysteine peptidase

Breast Carcinoma

MDA-MB-231

1.8 µM (72h)

-

-

-

In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised activation of caspase-3 (438%).

caspase 3, apoptosis-related cysteine peptidase

Breast Cancer

KPL-1

11.9 µM (72h)

-

-

-

In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised activation of caspase-3 (438%).

caspase 3, apoptosis-related cysteine peptidase

Breast Cancer

MKL-F

18.1 µM (72h)

-

-

-

In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised activation of caspase-3 (438%).

caspase 3, apoptosis-related cysteine peptidase

Breast adenocarcinoma

MCF-7

4.1 µM (72h)

-

-

-

In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised activation of caspase-3 (438%).

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.