NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Diallyldisulfide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Breast CarcinomaMDA-MB-2311.8 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in all four cell lines examined;the apoptosis cascade comprised up-regulation of Bax protein (142%).11375895
BAXBCL2-associated X protein581Breast CancerKPL-111.9 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised up-regulation of Bax protein (142%).11375895
BAXBCL2-associated X protein581Breast CancerMKL-F18.1 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised up-regulation of Bax protein (142%).11375895
BAXBCL2-associated X protein581Breast adenocarcinomaMCF-74.1 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised up-regulation of Bax protein (142%).11375895

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.