NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Chlorogenic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
GSTM1glutathione S-transferase mu 12944Murine epidermalJB6----Chlorogenic acid moderately increased glutathione S-transferases enzymatic activities in a dosedependent manner. After treatment of JB6 cells with chlorogenic acid at 40 and 80 M, glutathione S-transferases activities increased by 46.8%.15944151
JUNjun proto-oncogene3725Murine epidermalJB6----Pretreatment of cells with chlorogenic acid markedly inhibited TPA-induced AP-1 and NF-kappaB activity over a similar concentration range . At a concentration of 40 µM chlorogenic acid, TPA-induced AP-1 activation was suppressed by 30%.15944151
MAPK1mitogen-activated protein kinase 15594Murine epidermalJB6----At low concentrations, chlorogenic acid decreased the phosphorylation p38 kinase.15944151
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Murine epidermalJB6----Pretreatment of cells with chlorogenic acid markedly inhibited TPA-induced AP-1 and NF-kappaB activity over a similar concentration range . At a concentration of 40 µM chlorogenic acid, TPA-induced NF-kappaB activation was suppressed by 42%.15944151
NQO1NAD(P)H dehydrogenase, quinone 11728Murine epidermalJB6----Chlorogenic acid moderately increased NQO1 activities in a dosedependent manner. After treatment of JB6 cells with chlorogenic acid at 40 and 80 M, NQO1 activities increased by 47.1%.15944151

 






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