NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Cepharanthine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Liver CancerHUH7----Cepharanthine(CEP) stimulated a 4.2 ± 0.3-fold increase in caspase-3-like activities at 12 h and the treatment of HuH-7 cells with a specific and potent inhibitor of caspase-3 significantly blocked CEP-induced apoptotic cell death (cells viability in-creased to 82 ± 8% in the presence of 10lM caspase-3 inhibitor), thus indicating the CEP-induced cell death followed by caspase-3 activation.16412424

 






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