NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Capillarisin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Breast adenocarcinomaMCF7 (PMA induced)----Capillarisin significantly and selectively suppressed PMA-induced MMP-9 expression in MCF-7; These results indicate that capillarisin suppresses PMA-induced MMP-9 secretion through inhibition of its transcriptional activity in MCF-7 cells 18088599
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Breast adenocarcinomaMCF7 (PMA induced)----Capillarisin dramatically reduced the PMA-induced binding activity of NF-kappaB in a dose-dependent manner, whereas it did not affect on the PMA-induced binding activity of AP-1.18088599
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)5970Breast adenocarcinomaMCF7 (PMA induced)----PMA induced the phosphorylation of p65 and c-Jun, a major subunit of AP-1 , and capillarisin inhibited the phosphorylation of p65 in a dose-dependent manner. 18088599

 






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