NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: beta-caryophyllene oxide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Breast adenocarcinomaMCF-7----constitutive activation of AKT was suppressed by beta-caryophyllene oxide in a concentration-dependent manner21924548
AKT1v-akt murine thymoma viral oncogene homolog 1207Prostate CancerPC-3----constitutive activation of AKT was suppressed by beta-caryophyllene oxide in a concentration-dependent manner21924548
CASP3caspase 3, apoptosis-related cysteine peptidase836Prostate CancerPC-3----beta-caryophyllene oxideclearly induced the cleavage of procaspase-3 as observed by the disappearance of the procaspase-3 band and appearance of its cleaved forms. 21924548
CCND1cyclin D1595Prostate CancerPC-3----beta-caryophyllene oxide suppressed the expression of anti-apoptotic gene products in a concentration-dependent manner. beta-caryophyllene oxide repressed cell cycle protein (Cyclin D1)21924548
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Prostate CancerPC-3----beta-caryophyllene oxide induced the expression of p21 in a concentration-dependent manner in prostate tumor cells21924548
COX-2cytochrome c oxidase subunit II4513Prostate CancerPC-3----beta-caryophyllene oxide suppressed the expression of anti-apoptotic gene products in a concentration-dependent manner. beta-caryophyllene oxide repressed proteins linked with metastasis i.e. COX-221924548
MAPK1mitogen-activated protein kinase 15594Breast adenocarcinomaMCF-7----beta-caryophyllene oxide slightly upregulated the phosphorylation of p38 MAPK in the cancer cells.21924548
MAPK1mitogen-activated protein kinase 15594Prostate CancerPC-3----beta-caryophyllene oxide slightly upregulated the phosphorylation of p38 MAPK in the PC-3 cancer cells.21924548
MAPK1mitogen-activated protein kinase 15594Breast adenocarcinomaMCF-7----beta-caryophyllene oxide substantially induced the activation of ERK kinase at a concentration as low as 10 µM21924548
MAPK1mitogen-activated protein kinase 15594Prostate CancerPC-3----beta-caryophyllene oxide substantially induced the activation of ERK kinase at a concentration as low as 10 µM in PC-3 cancer cells.21924548
MAPK8mitogen-activated protein kinase 85599Breast adenocarcinomaMCF-7----beta-caryophyllene oxide slightly upregulated the phosphorylation of JNK in the MCF-7 cancer cells.21924548
MAPK8mitogen-activated protein kinase 85599Prostate CancerPC-3----beta-caryophyllene oxide slightly upregulated the phosphorylation of JNK in the PC-3 cancer cells.21924548
MTORmechanistic target of rapamycin (serine/threonine kinase)2475Breast adenocarcinomaMCF-7----constitutive activation of mTOR was suppressed by beta-caryophyllene oxide in a concentration-dependent manner21924548
MTORmechanistic target of rapamycin (serine/threonine kinase)2475Prostate CancerPC-3----constitutive activation of mTOR was suppressed by beta-caryophyllene oxide in a concentration-dependent manner21924548
PARP1poly (ADP-ribose) polymerase 1142Prostate CancerPC-3----beta-caryophyllene oxide induced PARP cleavage in a concentration-dependent manner21924548
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha5290Breast adenocarcinomaMCF-7----constitutive activation of PI3K was suppressed by beta-caryophyllene oxide in a concentration-dependent manner21924548
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha5290Prostate CancerPC-3----constitutive activation of PI3K was suppressed by beta-caryophyllene oxide in a concentration-dependent manner21924548
RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 16198Breast adenocarcinomaMCF-7----constitutive activation of S6K1 was suppressed by beta-caryophyllene oxide in a concentration-dependent manner21924548
RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 16198Prostate CancerPC-3----constitutive activation of S6K1 was suppressed by beta-caryophyllene oxide in a concentration-dependent manner21924548
TP53tumor protein p537157Prostate CancerPC-3----beta-caryophyllene oxide induced the expression of p53 in a concentration-dependent manner in prostate tumor cells21924548
VEGFAvascular endothelial growth factor A7422Prostate CancerPC-3----beta-caryophyllene oxide suppressed the expression of anti-apoptotic gene products in a concentration-dependent manner. beta-caryophyllene oxide repressed proteins linked with angiogenesis i.e. VEGF21924548

 






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