NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Actein

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Breast CarcinomaMDA-MB-453----Actein appeared to induce a biphasic response for the survival proteins; actein upregulated the activated forms at 20 and 40 µg/ml at 3 h and at 20 µg/ml at 8 and 24 h, but downregulated these protein levels at 40 µg/ml at 24 h18755149
ATF3activating transcription factor 3467Breast CarcinomaMDA-MB-453----Western blot analysis indicated that when MDA-MB-453 cells were treated with 40 lg/mL actein, they saw a slight induction of the ATF3 protein at 3 hr, a moderate induction at 8 hr and a very strong induction at 24 hr.17621630
CCND1cyclin D1595Breast CarcinomaMDA-MB-453----While actein at 20 µg/ml slightly increased the level of cyclin D1 protein at 3 and 24 h, actein at 40 µg/ml decreased the level of cyclin D1 protein at 3, 8, and 24 h in MDA-MB-453 cell18755149
MAPK1mitogen-activated protein kinase 15594Breast CarcinomaMDA-MB-453----Actein appeared to induce a biphasic response for the survival proteins; actein upregulated the activated forms at 20 and 40 µg/ml at 3 h and at 20 µg/ml at 8 and 24 h, but downregulated these protein levels at 40 µg/ml at 24 h18755149
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Breast CarcinomaMDA-MB-453----Actein induced a 1.59-fold increase in NF-kappaB promoter activity at 20 µg/ml and a 0.12-fold decrease at 40 µg/ml, at 24 h18755149
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)6714Breast CarcinomaMDA-MB-453----Treatment of serum-starved MDA-MB-453 cells with actein at 80 µg/ml (118 µM) for 30 min increased the level of p-Src by 1.5-fold.18755149

 






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