NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: (-)-anonaine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Cervix AdenocarcinomaHeLa----(-)-anonaine up-regulated the expression of Bax proteins in HeLa cancer cells.18524447
BCL2B-cell CLL/lymphoma 2596Cervix AdenocarcinomaHeLa----(-)-anonaine altered the expression of Bcl-2 proteins in HeLa cancer cells.18524447
CASP3caspase 3, apoptosis-related cysteine peptidase836Cervix AdenocarcinomaHeLa----Treatment with (-)-anonaine induces dose-dependent DNA damage that is correlated with increased intracellular nitric oxide, reactive oxygen species, glutathione depletion, disruptive mitochondrial transmembrane potential, activation of caspase 3 in HeLa cancer cells.18524447
CASP7caspase 7, apoptosis-related cysteine peptidase840Cervix AdenocarcinomaHeLa----Treatment with (-)-anonaine induces dose-dependent DNA damage that is correlated with increased intracellular nitric oxide, reactive oxygen species, glutathione depletion, disruptive mitochondrial transmembrane potential, activation of caspase 7 in HeLa cancer cells.18524447
CASP8caspase 8, apoptosis-related cysteine peptidase841Cervix AdenocarcinomaHeLa----Activities of caspases 8 and 9 were time dependently increased after (-)-anonaine treatment. Both activities of caspases 8 and 9 increased about 4-fold after 24 h of treatment.18524447
CASP9caspase 9, apoptosis-related cysteine peptidase842Cervix AdenocarcinomaHeLa----Activities of caspases 8 and 9 were timedependently increased after ()-anonaine treatment. Both activities of caspases 8 and 9 increased about 4-fold after 24 h of treatment.18524447
TP53tumor protein p537157Cervix AdenocarcinomaHeLa----(-)-anonaine up-regulated the expression of p53 proteins in HeLa cancer cells.18524447

 






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