Compound: Xerophilusin B

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

NOS2

nitric oxide synthase 2, inducible

4843

Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus

RAW264.7

The effects were tested of the ent-kauranes on NF-kB activation and the translocation of p65, as well as on IkB degradation. NF-kappaB activation was clearly reduced in the presence of test compounds 1-3 (1 µM), whereas compound 4 had no effect . In contrast, p65 translocation from the cytoplasm to the nucleus was inhibited by all four test compounds. Compound 4 again exhibited a different behavior in that its effect was dependent on the amount of LPS stimulation time. Finally, all four ent-kauranes tested were found to inhibit the LPSinduced degradation of IkB .

19719246

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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