NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Xanthohumol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
COX-1cytochrome c oxidase subunit I4512Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.716.6 µM---It potently inhibits cyclooxygenase 1 (Cox-1) activity and it is an anti-inflammatory mechanism.Phytochemistry Reviews 1: 369-377, 2002
COX-2cytochrome c oxidase subunit II4513Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.741.5 µM---At a test concentration of 100 µM, xanthoumol inhibited Cox-2 activity 83%, and they determined an IC50 of 41.5 µM for xanthohumol.Phytochemistry Reviews 1: 369-377, 2002
CYPIA1cytochrome P450, family 1, subfamily A, polypeptide 11543Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.70.02 µM---The chalcone xanthohumol isolated from beer potently inhibited Cyp1A activity, with IC50 0.02 µM.Cyp1A, which is e.g. involved in the activation of carcinogens from grilled meat, as a model phase 1 enzyme, and measured the potential of beer constituents to inhibit its enzymatic activity.Phytochemistry Reviews 1: 369-377, 2002
NOS2nitric oxide synthase 2, inducible4843Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.712.9 µM---Nitric oxide (NO) synthase (iNOS) and consequently, enhance the generation of NO. Generally, NO is an important signaling molecule, long-term elevated levels of NO, however, have been linked to early steps in carcinogenesis.It cause inhibition of lipopolysaccharide (LPS)-mediated induction of inducible nitric oxide synthase , which is an anti-inflammatory mechanis.Phytochemistry Reviews 1: 369-377, 2002
NQO1NAD(P)H dehydrogenase, quinone 11728Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.77.4 µM---It induces the QR activity.Induction of phases 2 enzymes contributes to chemopreventive activity. QR is not catalyzing a conjugation reaction, but it is induced co-ordinately with other phase 2 enzymes and contributes to detoxification by reduction of reactive quinones to less reactive hydroquinones.Phytochemistry Reviews 1: 369-377, 2002

 






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