NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Tricin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CDC25Ccell division cycle 25 homolog C (S. pombe)995Breast CarcinomaMDA-MB-468----Cdc 25, a protein regulator of cell-cycle transition at G2/M checkpoints as potential candidate targets with which tricin might engage in causing growth arrest. The kinase cdc 25 activate the p34cdc2-cyclin B1 complex.15316567
CDK1cyclin-dependent kinase 1983Breast CarcinomaMDA-MB-468----p34cdc2, a protein regulator of cell-cycle transition at G2/M checkpoints as potential candidate targets with which tricin might engage in causing growth arrest. p34cdc2 is a cyclin-dependent kinase, which in association with cyclin B1 controls transition of the cell from G2 into M phase.15316567
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Breast CarcinomaMDA-MB-468----p21cip, a protein regulator of cell-cycle transition at G2/M checkpoints as potential candidate targets with which tricin might engage in causing growth arrest p21cip is a cyclin-dependent kinase inhibitor, which associates with the p34cdc2-cyclin B1 complex and promotes a block in both G2 and G1 phases.15316567
WEE1WEE1 homolog (S. pombe)7465Breast CarcinomaMDA-MB-468----Wee 1, a protein regulator of cell-cycle transition at G2/M checkpoints as potential candidate targets with which tricin might engage in causing growth arrest. The kinase Wee1 inhibit the p34cdc2-cyclin B1 comple.15316567

 






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