NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Toosendanin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Hepatocellular CarcinomaH22----The number of Bax positive cells and the mean optical density in the CTX and toosendanin groups were higher than in the control group.20157879
BCL2B-cell CLL/lymphoma 2596Hepatocellular CarcinomaH22----The number of Bcl-2 positive cells was significantly reduced compared to the control groups.20157879
CASP3caspase 3, apoptosis-related cysteine peptidase836Rat pheochromocytomaPC-12----It is believed that the cytochrome c release from the mitochondria into the cytosol was followed by the activation of caspases. And it was reported that caspase-3 is expressed in PC12 cell.15297017
CYCScytochrome c54205Rat pheochromocytomaPC-12----Toosendanin induced cytochrome c release from the mitochondria. As shown,cytochrome c in the cytosol of the cells could be detected since 24 h of treatment with toosendanin and lasted up to 72 h. These data indicated that cytochrome c release was involved in toosendanin-induced apoptosi.15297017
FasTNF receptor superfamily, member 6355Hepatocellular CarcinomaH22----The number of Fas positive cells and the mean optical density in the CTX and toosendanin groups were higher than in the control group.20157879

 






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