NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Tangeretin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 15243Colorectal AdenocarcinomaCaCo-2----They conclude that this methoxyflavone enhanced vinblastine uptake by specifically inhibiting drug efflux via P-gp. This may have potential as agent for reversing multidrug resistance or for recovering the bioavailability of certain drugs. The steady-state uptake of [3H]vinblastine was increased by tangeretin in a concentration-dependent manner, and the uptakes amounted to 906 ± 23.6% of the control, in the presence of 50µM methoxyflavones.10734174
CCND1cyclin D1595Colon CancerCOLO-205----tangeretin appeared to have a suppressing effect on the levels of cyclin D112376477
CCNE1cyclin E1898Colon CancerCOLO-205----tangeretin appeared to have a suppressing effect on the levels of cyclin E12376477
CDK2cyclin-dependent kinase 21017Colon CancerCOLO-205----the inhibition of Cdk 2 activity by tangeretin were also concentration-dependent in cultured COLO 205 cell.12376477
CDK4cyclin-dependent kinase 41019Colon CancerCOLO-205----the inhibition of Cdk 4 activity by tangeretin were also concentration-dependent in cultured COLO 205 cell.12376477
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Colon CancerCOLO-205----tangeretin markedly up-regulated the level of p27 in a concentration-dependent manne.12376477
CycACyclin A39340Colon CancerCOLO-205----tangeretin appeared to have a suppressing effect on the levels of cyclin A12376477
PSMD9proteasome (prosome, macropain) 26S subunit, non-ATPase, 95715Colon CancerCOLO-205----tangeretin markedly up-regulated the level of p21 in a concentration-dependent manne.12376477
RB1retinoblastoma 15925Colon CancerCOLO-205----the degree of phosphorylation of Rb was decreased after 12 h of 50 µM tangeretin treatment compared with total Rb protei.12376477

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.