NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Squamocin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MAPK8mitogen-activated protein kinase 85599Colon cancerSW-620----squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis.21299907
MAPK8mitogen-activated protein kinase 85599Human Glioblastoma MultiformeGBM8401----squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis.21299907
MAPK8mitogen-activated protein kinase 85599Liver CancerHUH7----squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis.21299907

 






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