NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Squamocin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AURKBaurora kinase B9212Colon cancerSW-620----Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of MSK1 in cancer cells and decreased the phosphorylated MSK1 (pMSK1).21299907
AURKBaurora kinase B9212Human Glioblastoma MultiformeGBM8401----Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of MSK1 in cancer cells and decreased the phosphorylated MSK1 (pMSK1).21299907
AURKBaurora kinase B9212Liver CancerHUH7----Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of MSK1 in cancer cells and decreased the phosphorylated MSK1 (pMSK1).21299907
BADBCL2-associated agonist of cell death572Bladder CancerT24----Squamocin significantly enhanced the expression of Bad at 1, 4, 8, 12, and 24 h after treatment.16154156
BAXBCL2-associated X protein581Bladder CancerT24----Squamocin significantly enhanced the expression of Bax at 1, 4, 8, 12, and 24 h after treatment.16154156
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon cancerSW-620----Squamocin enhanced caspase-3 activities and cause apoptosis.21299907
CASP3caspase 3, apoptosis-related cysteine peptidase836Human Glioblastoma MultiformeGBM8401----Squamocin enhanced caspase-3 activities and cause apoptosis.21299907
CASP3caspase 3, apoptosis-related cysteine peptidase836Liver CancerHUH7----Squamocin enhanced caspase-3 activities and cause apoptosis.21299907
CASP3caspase 3, apoptosis-related cysteine peptidase836Bladder CancerT24----The expression of procaspase-3 was induced by 10 µg/mL of squamocin at 1 h and greater time points via cleavage.16154156
CASP8caspase 8, apoptosis-related cysteine peptidase841Colon cancerSW-620----Squamocin enhanced caspase-8 activities and cause apoptosis.21299907
CASP8caspase 8, apoptosis-related cysteine peptidase841Human Glioblastoma MultiformeGBM8401----Squamocin enhanced caspase-8 activities and cause apoptosis.21299907
CASP8caspase 8, apoptosis-related cysteine peptidase841Liver CancerHUH7----Squamocin enhanced caspase-8 activities and cause apoptosis.21299907
CASP9caspase 9, apoptosis-related cysteine peptidase842Colon cancerSW-620----Squamocin enhanced caspase-9 activities and cause apoptosis.21299907
CASP9caspase 9, apoptosis-related cysteine peptidase842Human Glioblastoma MultiformeGBM8401----Squamocin enhanced caspase-9 activities and cause apoptosis.21299907
CASP9caspase 9, apoptosis-related cysteine peptidase842Liver CancerHUH7----Squamocin enhanced caspase-9 activities and cause apoptosis.21299907
MAPK1mitogen-activated protein kinase 15594Colon cancerSW-620----Squamocin treatment significantly decreased ERK phosphorylation (pERK) levels and ERK is connected to cell survival.21299907
MAPK1mitogen-activated protein kinase 15594Human Glioblastoma MultiformeGBM8401----Squamocin treatment significantly decreased ERK phosphorylation (pERK) levels and ERK is connected to cell survival.21299907
MAPK1mitogen-activated protein kinase 15594Liver CancerHUH7----Squamocin treatment significantly decreased ERK phosphorylation (pERK) levels and ERK is connected to cell survival.21299907
MAPK8mitogen-activated protein kinase 85599Colon cancerSW-620----squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis.21299907
MAPK8mitogen-activated protein kinase 85599Human Glioblastoma MultiformeGBM8401----squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis.21299907
MAPK8mitogen-activated protein kinase 85599Liver CancerHUH7----squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis.21299907
PARP1poly (ADP-ribose) polymerase 1142Bladder CancerT24----The function of PARP was destroyed by 10 µg/mL of squamocin at 1 h and greater time points via cleavage.16154156
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 59252Colon cancerSW-620----Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of Aurora B in cancer cells and decreased the protein expression levels of aurora .21299907
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 59252Human Glioblastoma MultiformeGBM8401----Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of Aurora B in cancer cells and decreased the protein expression levels of aurora .21299907
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 59252Liver CancerHUH7----Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of Aurora B in cancer cells and decreased the protein expression levels of aurora .21299907

 






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