NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Sesamin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Breast adenocarcinomaMCF-7----Akt was activated (by phosphorylation) in MCF-7 cells within 1-h MøCM treatment, and Akt activities were potently inhibited by sesamin.20617373
CCND1cyclin D1595Breast adenocarcinomaMCF-7----Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein.17640297
CCND1cyclin D1595Breast CarcinomaT-47D----Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein.17640297
CCND1cyclin D1595Lung adenocarcinomaA549----Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein.17640297
CCND1cyclin D1595MelanomaUACC-62----Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein.17640297
CCND1cyclin D1595OsteosarcomaMG63----Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein.17640297
HIF1Ahypoxia inducible factor 13091Breast adenocarcinomaMCF-7----HIF-1alpha was induced in the nuclear extract of MCF-7 cells after MøCM treatment, and the induction was attenuated by sesamin.20617373
IL6interleukin 63569Breast adenocarcinomaMCF-7----The levels of IL-6,was induced in MCF-7 cells when incubated with MfCM; additionally, sesamin was able to inhibit MfCM-induced IL-6 mRNA expression in a concentration-dependent manner.20617373
IL8interleukin 83576Breast adenocarcinomaMCF-7----The levels of IL-8 mRNA were all induced in MCF-7 cells when incubated with MfCM; additionally, sesamin was able to inhibit MfCM-induced IL-8, expression in a concentration-dependent manner.20617373
MAPK1mitogen-activated protein kinase 15594Breast adenocarcinomaMCF-7----p38MAPK was activated (by phosphorylation) in MCF-7 cells within 1-h MøCM treatment, and p38MAPK activities were potently inhibited by sesamin.20617373
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Breast CarcinomaMDA-MB-231----inhibitory effect of sesamin on macrophage-induced MMP-9 expression was also observed with MDA-MB-231 cell.20617373
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Breast adenocarcinomaMCF-7----MMP-9 mRNA expression was also induced in the MCF-7 cells after incubated with MfCM for 4 or 8 h, and sesamin was able to inhibit this MMP-9 mRNA induction.20617373
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Breast adenocarcinomaMCF-7----NF-kappaB was induced in the nuclear extract of MCF-7 cells after MøCM treatment, and the induction was attenuated by sesamin.20617373
PLCG1phospholipase C, gamma 15335Breast adenocarcinomaMCF-7----It is suggested that inhibition of PLC gamma 1 by this compound may be an important mechanism for an antiproliferative effect on the human cancer cells.15554262
PLCG1phospholipase C, gamma 15335Colon CancerHCT-15----It is suggested that inhibition of PLC gamma 1 by this compound may be an important mechanism for an antiproliferative effect on the human cancer cells.15554262
PLCG1phospholipase C, gamma 15335Lung adenocarcinomaA549----It is suggested that inhibition of PLC gamma 1 by this compound may be an important mechanism for an antiproliferative effect on the human cancer cells.15554262
RB1retinoblastoma 15925Breast adenocarcinomaMCF-7----A hyperphosphorylated form of RB protein began to be converted into a hypophosphorylated form 3 h after treatment with sesamin.17640297
TNFtumor necrosis factor7124Breast adenocarcinomaMCF-7----The levels of TNF-alpha mRNA were all induced in MCF-7 cells when incubated with MfCM; additionally, sesamin was able to inhibit MfCM-induced TNF-alpha mRNA expression in a concentration-dependent manner.20617373
VEGFAvascular endothelial growth factor A7422Breast CarcinomaMDA-MB-231----inhibitory effect of sesamin on macrophage-induced VEGF expression was also observed with MDA-MB-231 cell.20617373
VEGFAvascular endothelial growth factor A7422Breast adenocarcinomaMCF-7----production of VEGF was significantly enhanced when MCF-7 cells were treated 24 h with MfCM compared with control treatment (454.5±81.2 vs. 207.9±50.6 pg/ml, P<0.05).20617373

 






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