NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Sanguinarine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
birc5abaculoviral IAP repeat-containing 5a373110Prostate CancerDU145----The tumor growth in sanguinarine-treated group was suppressed starting at 31 days post cell inoculation and throughout the treatment period until 56 days when the mice were sacrificed . The levels of survivin protein expression in tumors were decreased in sanguinarine treatment group compared to the control group. These data demonstrated that sanguinarine was able to suppress the tumor growth of DU145 human prostate cancer cells.21318089
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790LeukemiaU-937----sanguinarine completely blocked the activation of NF-kB induced by TNF, IL-1, phorbol ester, and OA but not that activated by H2O2 and ceramide.9374492
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790T cell leukemiaJurkat T----sanguinarine completely blocked the activation of NF-kB induced by TNF, IL-1, phorbol ester, and OA but not that activated by H2O2 and ceramide.9374492

 






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