NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Saikosaponin D

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
TP53tumor protein p537157Lung adenocarcinomaA549----The up-regulation of p53 by Saikosaponin D can be appreciated from the 6th hour of treatment, the highest effect being observed after 12 hours of incubation with the drug. Comparison of the results between apoptotic response and induction of p53 indicated that the up-regulation of p53 occurred at an early stage of Saikosaponin D-mediated apoptotic process.15219811

 






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