NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Saikosaponin D

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP8caspase 8, apoptosis-related cysteine peptidase841Lung adenocarcinomaA549----The results showed that caspase-8 activity increased at 12 h, and reached maximum induction at 24 h in 20 AM Saikosaponin D treated A549 cells. Furthermore, our results showed that the antiproliferative activity and induction of apoptosis by Saikosaponin D were significantly decreased in the presence of inhibitor of caspase-8.15219811

 






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