NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Rutin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CCND1cyclin D1595Colon carcinogenesis-----Positive Cyclin D1 expression was detected in mice on diets supplemented by rutin(P<0.005). Supplementation of rutin in a standard diet result in the expression of Cyclin D1 in normal colonic cells.10964096
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929->250 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-250±9 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415

 






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