NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Rhinacanthin C

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Cervix AdenocarcinomaHela-S3----rhinacanthins-C and -N treatment caused the activation of caspase-3 in a dose-dependent manner after 48h exposure, whereas the activity was decreased at a highest concentration of rhinacanthin-Q. Rhinacanthin-N (90 mM), the most effective drug, induced a marked increase in caspase-3 activity to 2.5 fold over the control cells. .17015953
COX-2cytochrome c oxidase subunit II4513Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----The mechanisms in transcriptional level of rhinacanthin-C were found to inhibit COX-2 gene expression.19303271
PTGER3prostaglandin E receptor 3 (subtype EP3)5733Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.710.4 µM---It was found that rhinacanthin-C exhibited the most potent PGE2 release withanIC50 value of 10.4 mM.19303271

 






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