NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Quercetin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Epidermal CarcinomaA431-III----Quercetin was able to directly inhibit the phosphorylation of Akt and thus reduce phosphorylation of GSK3b by 43% on treatment with Qu.21752154
CCND1cyclin D1595Colon carcinogenesis-----Positive Cyclin D1 expression was detected in mice on diets supplemented by quercetin(P<0.001). Supplementation of quercetin in a standard diet result in the expression of Cyclin D1 in normal colonic cells.10964096
CDH1cadherin 1, type 1, E-cadherin999Epidermal CarcinomaA431-III----Quercetin moderetly increased E-cadherin levels in terms of both protein and mRNA in a dose-dependent manner.21752154
CDH1cadherin 1, type 1, E-cadherin999Epidermal CarcinomaA431-P----Quercetin moderetly increased E-cadherin levels in terms of both protein and mRNA in a dose-dependent manner.21752154
CDH1cadherin 1, type 1, E-cadherin999Epidermal CarcinomaA431-III----Reversed cadherin switching, downregulated EMT markers, and nullified the invasion ability of A431-III cells.21752154
CDH1cadherin 1, type 1, E-cadherin999Epidermal CarcinomaA431-P----Reversed cadherin switching, downregulated EMT markers, and nullified the invasion ability of A431-III cells.21752154
CDH2cadherin 2, type 1, N-cadherin (neuronal)1000Epidermal CarcinomaA431-III----Quercetin markedly reduced N-cadherin levels in terms of both protein and mRNA in a dose-dependent manner.21752154
CDH2cadherin 2, type 1, N-cadherin (neuronal)1000Epidermal CarcinomaA431-P----Quercetin markedly reduced N-cadherin levels in terms of both protein and mRNA in a dose-dependent manner.21752154
CDK2cyclin-dependent kinase 21017Human MelanomaOCM-1----Quercetin, which induced a cell cycle block in G1, inhibited the activity of CDK-2 by 40-60%.11322924
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Human MelanomaOCM-1----Quercetin also increased the content of p21CIP1 but lately (after 48-72 hr) and to a lower extent.11322924
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)1027Human MelanomaOCM-1----Quercetin markedly upregulated the level of p27KIP1 within 24 hr (and until 48-72 hr).11322924
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Epidermal CarcinomaA431-P----Cells were treated with different concentrations(10-40 µM) of Quercetin for 24 h. The results showed that treatment with quercetin dose-dependently decreased MMP-9 activity in the conditioned medi.21752154
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Epidermal CarcinomaA431-III----Cells were treated with different concentrations(10-40 µM) of Quercetin for 24 h. The results showed that treatment with Quercetin dose-dependently decreased MMP-9 activity in the conditioned medium.21752154
SNAI1snail homolog 1 (Drosophila)6615Epidermal CarcinomaA431-III----Treatment with Quercetin dramatically reduced the protein and mRNA levels of Snail in A431-III cells in a dose dependent manner.21752154
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-20±4 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-26±6 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415
TWIST1twist homolog 1 (Drosophila)7291Epidermal CarcinomaA431-III----Treatment with Quercetin dramatically reduced the protein and mRNA levels of Twist in A431-III cells in a dose dependent manner.21752154

 






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