NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Puerarin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Colon CancerHT-29----The bax protein expression level was slightly increased compared to the vehicle control.16055262
BAXBCL2-associated X protein581Breast adenocarcinomaMCF-7----The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax,as revealed by western blottin.19013426
BCL2B-cell CLL/lymphoma 2596Colon CancerHT-29----The treatment of the HT-29 cells with the puerarin resulted in a marked decrease of the bcl-2 at protein levels in a dose-dependent manner.16055262
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon CancerHT-29----Caspase-3 activity was upregulated after 72 h of treatments with given concentrations of puerarin.16055262
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast CarcinomaHs578T----It induced cell apoptosis through a caspase-3-dependent pathway and mediated cell cycle arrest in the G2/M phase. The induction of apoptosis in the breast cancer cell lines by genistein isoflavone confirmed by detection of increased caspase-3 activity in the isoflavone-treated HS578T and MDA-MB-231 cells.19013426
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast CarcinomaMDA-MB-231----It induced cell apoptosis through a caspase-3-dependent pathway and mediated cell cycle arrest in the G2/M phase. The induction of apoptosis in the breast cancer cell lines by genistein isoflavone confirmed by detection of increased caspase-3 activity in the isoflavone-treated HS578T and MDA-MB-231 cells.19013426
CASP9caspase 9, apoptosis-related cysteine peptidase842Breast adenocarcinomaMCF-7----The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax,as revealed by western blottin.19013426
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Breast adenocarcinomaMCF-7----The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax,as revealed by western blottin.19013426
MYCv-myc myelocytomatosis viral oncogene4609Colon CancerHT-29----The treatment of the HT-29 cells with the puerarin resulted in a marked decrease of the c-myc at protein levels in a dose-dependent manner.16055262
TP53tumor protein p537157Breast adenocarcinomaMCF-7----The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax,as revealed by western blottin.19013426

 






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