NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: protocatechuic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)4313Gastric CancerAGS----the effect of PCA on MMP activities was investigated by gelatin-zymography under conditions of serum starvation to clarify the contribution of MMPs to the inhibition by PCA of the invasive ability of cells. MMP-2 activity was reduced by PCA in a concentration-dependent manner, whereas there was little effect on MMP-9 activity. Time-course experiments with PCA at a lower concentration of 1.0 mM revealed a prolonged inhibition of MMP-2 activity in AGS cells, in a time-dependent manne.20840540

 






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