NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: protocatechuic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Gastric CancerAGS----the activity of MMP-2 and cellular levels of p-Akt and nuclear NF-kB were decreased at the same time as the PKCe and RhoB expression increased in the protocatechuic acid-treated AGS cells for 24 h.20840540
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)4313Gastric CancerAGS----the effect of PCA on MMP activities was investigated by gelatin-zymography under conditions of serum starvation to clarify the contribution of MMPs to the inhibition by PCA of the invasive ability of cells. MMP-2 activity was reduced by PCA in a concentration-dependent manner, whereas there was little effect on MMP-9 activity. Time-course experiments with PCA at a lower concentration of 1.0 mM revealed a prolonged inhibition of MMP-2 activity in AGS cells, in a time-dependent manne.20840540
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Gastric CancerAGS----the effect of PCA on MMP activities was investigated by gelatin-zymography under conditions of serum starvation to clarify the contribution of MMPs to the inhibition by PCA of the invasive ability of cells. MMP-2 activity was reduced by PCA in a concentration-dependent manner, whereas there was little effect on MMP-9 activity. Time-course experiments with PCA at a lower concentration of 1.0 mM revealed a prolonged inhibition of MMP-2 activity in AGS cells, in a time-dependent manne.20840540
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Gastric CancerAGS----the transfection of NF-kB p65 cDNA into AGS cells resulted in increased expression of NF-kB, concomitantly with a marked induction of cell invasion.20840540
RHOBras homolog family member B388Gastric CancerAGS----The activity of MMP-2 and cellular levels of p-Akt and nuclear NF-kB were decreased at the same time as the PKCe and RhoB expression increased in the protocatechuic acid-treated AGS cells for 24 h.20840540
TIMP2TIMP metallopeptidase inhibitor 27077Gastric CancerAGS----These PCA-induced changes in the mRNA levels of MMP-2 and TIMP-2 coincided well with their protein levels, as shown by Western blots,indicating that PCA might regulate MMP-2 and TIMP-2 expressions at the transcriptional level.20840540

 






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