NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Poncirin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Gastric CancerAGS----Western blot results showed that expression level of Bax was increased in a dose-dependent manner.22194772
BCL2L1BCL2-like 1598Gastric CancerAGS----Western blot results showed that expression level of Bcl-xL was decreased in a dose-dependent manner.22194772
CASP3caspase 3, apoptosis-related cysteine peptidase836Gastric CancerAGS----Flavonoids caused downregulation of procaspase-3 which consequently increased the activity of caspase-3.22194772
CCNB1cyclin B1891Gastric CancerAGS----It reduces the protein level of cyclin B1 in a dose-dependent manner.Decrease of cyclin B1 expression might be a molecular mechanism through which flavonoids induce G2/M arrest.22194772
CDC25Ccell division cycle 25 homolog C (S. pombe)995Gastric CancerAGS----It reduces the protein level of cdc 25c in a dose-dependent manner.Decrease of cdc 25c expression might be a molecular mechanism through which flavonoids induce G2/M arrest.22194772
CDK1cyclin-dependent kinase 1983Gastric CancerAGS----It reduces the protein level of cdc 2 in a dose-dependent manner.Decrease of cdc 2 expression might be a molecular mechanism through which flavonoids induce G2/M arrest.22194772
PARP1poly (ADP-ribose) polymerase 1142Gastric CancerAGS----During apoptosis, caspases induce PARP cleavage and inactivation and cleavage of PARP helps cellular disassembly and is a marker of cells undergoing apoptosis.22194772

 






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