NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Plumbagin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha5290Breast CarcinomaMDA-MB-231----Plumbagin treatment of cells was found to cause a significant reduction in the expression of the regulatory subunit of PI3K (p85) protei.17172425
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha5290Breast cancerMDA-MB-231----Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of PI3K (p85) regulatory subunit was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice.17172425

 






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