NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Plumbagin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MTORmechanistic target of rapamycin (serine/threonine kinase)2475Breast cancerMDA-MB-231----Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. The levels of phospho-mTOR were lower in the tumors from the plumbagin-treated group when compared with the tumors from vehicle-treated mice.17172425

 






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