| MTOR | mechanistic target of rapamycin (serine/threonine kinase) | 2475 | Breast cancer | MDA-MB-231 | - | - | - | - | Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. The levels of phospho-mTOR were lower in the tumors from the plumbagin-treated group when compared with the tumors from vehicle-treated mice. | 17172425 |