NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Plumbagin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Breast CarcinomaMDA-MB-231----Results show that plumbagin targets the AKT signaling pathway. It can be firmly concluded that plumbagin induces autophagic cell death in MDA-MB-231 by suppression of the AKT pathway.17172425
AKT1v-akt murine thymoma viral oncogene homolog 1207Breast cancerMDA-MB-231----Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of phospho-AKT was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice.17172425
BCL2B-cell CLL/lymphoma 2596Breast CarcinomaMDA-MB-231----MDA-MB-231 cells treated with increasing concentrations of plumbagin for 24 and 72 h showed down-regulation of anti-apoptotic protein Bcl-2.18980240
BCL2B-cell CLL/lymphoma 2596Breast adenocarcinomaMCF-7----Plumbagin-Induced Apoptosis of human breast cancer cells s mediated by inactivation of Bcl-.18980240
CASP3caspase 3, apoptosis-related cysteine peptidase836Epidermoid cervical carcinomaME-180----There was a 2.5-fold increase in the caspase-3 activation on treatment with plumbagin.15264212
MTORmechanistic target of rapamycin (serine/threonine kinase)2475Breast cancerMDA-MB-231----Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. The levels of phospho-mTOR were lower in the tumors from the plumbagin-treated group when compared with the tumors from vehicle-treated mice.17172425
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Breast adenocarcinomaMCF-7----Induction of apoptosis in breast cancer cells by plumbagin could be mechanistically linked with the inactivation of NF-k.18980240
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Breast CarcinomaMDA-MB-231----Induction of apoptosis in breast cancer cells by plumbagin could be mechanistically linked with the inactivation of NF-k.18980240
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha5290Breast CarcinomaMDA-MB-231----Plumbagin treatment of cells was found to cause a significant reduction in the expression of the regulatory subunit of PI3K (p85) protei.17172425
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha5290Breast cancerMDA-MB-231----Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of PI3K (p85) regulatory subunit was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice.17172425

 






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