NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: P-hydroxymethoxybenzobijuglone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Cervix AdenocarcinomaHeLa----After HeLa cells were treated with 9.2, 16.8, and 21.8 mM HMBBJ for 48 h, compared to control cells, Bax protein expression level was increased in HMBBJ-treated HeLa cells (from 7.671.48% to 22.573.98%).17959366
BCL2B-cell CLL/lymphoma 2596Cervix AdenocarcinomaHeLa----After HeLa cells were treated with 9.2, 16.8, and 21.8 mM HMBBJ for 48 h, compared to control cells, Bcl-2 protein expression level was markedly decreased (from 61.274.63% to 39.873.24%.17959366
CASP3caspase 3, apoptosis-related cysteine peptidase836Cervix AdenocarcinomaHeLa----Following 48 h treatment of HeLa cells with various concentrations of HMBBJ, we detected both increase of caspase-3 like activities compared with the control cell.17959366
CASP8caspase 8, apoptosis-related cysteine peptidase841Cervix AdenocarcinomaHeLa----Following 48 h treatment of HeLa cells with various concentrations of HMBBJ, we detected both increase of caspase-8 like activities compared with the control cell.17959366

 






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