NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Pheophorbide A

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

mitogen-activated protein kinase 1

Breast Carcinoma

MDA-MB-231

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-

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results therefore implied that ERK could mediate autophagy, and the induced autophagy enhanced the anti-tumor effect of Pa-PDT on MDA-MB-231 cells.

mitogen-activated protein kinase 1

Breast Carcinoma

MDA-MB-231

-

-

-

-

Significant phosphorylation of JNK and mild activation of p38 were foun.

mitogen-activated protein kinase 1

Breast Carcinoma

MDA-MB-231

-

-

-

-

The phosphorylation of JNK was increased in a dose-dependent manner whereas the phosphorylation of ERK was slightly increased at 0.5 Mand strongly suppressed at higher concentration of Pa-PDT in the treated cell.

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.