NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Pheophorbide A

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

calreticulin

Breast Carcinoma

MDA-MB-231

-

-

-

-

increase of calreticulin was observed at the early time in a dose-dependent manne.

glucose-regulated protein, 78kDa

Breast Carcinoma

MDA-MB-231

-

-

-

-

decrease of GRP78/BiP was observed at the early time in a dose-dependent manne.

mitogen-activated protein kinase 1

Breast Carcinoma

MDA-MB-231

-

-

-

-

results therefore implied that ERK could mediate autophagy, and the induced autophagy enhanced the anti-tumor effect of Pa-PDT on MDA-MB-231 cells.

mitogen-activated protein kinase 1

Breast Carcinoma

MDA-MB-231

-

-

-

-

Significant phosphorylation of JNK and mild activation of p38 were foun.

mitogen-activated protein kinase 1

Breast Carcinoma

MDA-MB-231

-

-

-

-

The phosphorylation of JNK was increased in a dose-dependent manner whereas the phosphorylation of ERK was slightly increased at 0.5 Mand strongly suppressed at higher concentration of Pa-PDT in the treated cell.

mitogen-activated protein kinase 8

Breast Carcinoma

MDA-MB-231

-

-

-

-

The phosphorylation of JNK was increased in a dose-dependent manner whereas the phosphorylation of ERK was slightly increased at 0.5 Mand strongly suppressed at higher concentration of Pa-PDT in the treated cell.

protein disulfide isomerase family A, member 3

Breast Carcinoma

MDA-MB-231

-

-

-

-

increase of ERp57 was observed at the early time in a dose-dependent manne.

c-ros oncogene 1 , receptor tyrosine kinase

Breast Carcinoma

MDA-MB-231

-

-

-

-

Intracellular ROS level was increased in a dose-dependent manner during Pa-PDT treatment.

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.