NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Peonidin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
COX-1cytochrome c oxidase subunit I4512Breast adenocarcinomaMCF-7----Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities.12925310
COX-1cytochrome c oxidase subunit I4512CNS CancerSF-268----Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities.12925310
COX-1cytochrome c oxidase subunit I4512Colon cancerHCT-116----Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities.12925310
COX-1cytochrome c oxidase subunit I4512Non-small cell lung cancerNCl-H460----Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities.12925310
COX-2cytochrome c oxidase subunit II4513Breast adenocarcinomaMCF-7----Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities.12925310
COX-2cytochrome c oxidase subunit II4513CNS CancerSF-268----Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities.12925310
COX-2cytochrome c oxidase subunit II4513Colon cancerHCT-116----Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities.12925310
COX-2cytochrome c oxidase subunit II4513Non-small cell lung cancerNCl-H460----Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities.12925310
COX-2cytochrome c oxidase subunit II4513Mouse EpidermalJB6 P+ ----They evaluated the ability of peonidin to inhibit TPA-induced COX-2 expression in JB6 P+ cells, and found that peonidin suppressed the expression of COX-2 in a concentration-dependent manner.17404064
MAPK1mitogen-activated protein kinase 15594Mouse EpidermalJB6 P+ ----It was found that TPA strongly induced phosphorylation of ERK-2 in JB6 P+ cells, and that this was blocked by 20 µM peonidin.17404064
MAPK3mitogen-activated protein kinase 35595Mouse EpidermalJB6 P+ ----It was found that TPA strongly induced phosphorylation of ERK-1 in JB6 P+ cells, and that this was blocked by 20 µM peonidin.17404064

 






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