NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Parthenolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
IL1Binterleukin 1, beta3553Hepatocellular carcinomaSH-J1----The transfected cells were exposed to 5 M parthenolide for 48 h . The change in luciferase activity, expressed relative to the level in untreated control cells,indicated that parthenolide increased GADD153 promoter activation maximally after 24 h of exposure, which preceded the increase of endogenous GADD153 mRNA after 36 h of treatment with parthenolide. These results suggest that parthenolide transcriptionally regulates GADD153 mRNA expression in SH-J1 cells.12151389

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.