| IL1B | interleukin 1, beta | 3553 | Hepatocellular carcinoma | SH-J1 | - | - | - | - | The transfected cells were exposed to 5 M parthenolide for 48 h . The change in luciferase activity, expressed relative to the level in untreated control cells,indicated that parthenolide increased GADD153 promoter activation maximally after 24 h of exposure, which preceded the increase of endogenous GADD153 mRNA after 36 h of treatment with parthenolide. These results suggest that parthenolide transcriptionally regulates GADD153 mRNA expression in SH-J1 cells. | 12151389 |