Compound: Panduratin A

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

MMP9

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

4318

Epidermoid Nasopharyngeal Cancer

MMP-9 protein and mRNA levels were significantly decreased after panduratin A treatment (p 0.05).

19122290

NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

4790

Lung adenocarcinoma

A549

Treatment with an apoptosis-inducing concentration of panduratin A resulted in significant inhibition of Nuclear Factor-kappa Beta (NF-kappaB) translocation from cytoplasm to nuclei activated by tumor necrosis factor- alpha (TNF-alpha), as illustrated by the HCS assay.

21441862

PLAU

plasminogen activator, urokinase

5328

Epidermoid Nasopharyngeal Cancer

It was found that uPA mRNA expression was downregulated by panduratin A. At 25 mM, panduratin A reduced uPA mRNA expression up to 37%.

19122290

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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