| MAPK1 | mitogen-activated protein kinase 1 | 5594 | Breast Carcinoma | MDA-MB-435 | - | - | - | - | Blocking the activity of p38 greatly reversed the stimulation of apoptosis by 4 nM paclitaxel, whereas, on the contrary, activating either kinase during paclitaxel treatment resulted in an increase of the effect of 0.5 nM paclitaxel on apoptosis. These results suggest that p38 PKA activation precede paclitaxel-dependent apoptosis and form part of its mechanism of action. | 12796407 |