NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Oleanolic acid 3-O-beta-D-glucopyranosyl-(1->3)-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
COX-2cytochrome c oxidase subunit II4513Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----COX-2 was inhibited by OA in LPS (1 µg/ml) induced raw 264.7 cell lines.17910942
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----Western blot analysis revealed that OA drastically reduced NF-kappaB translocation by the inhibition effects of LPS-induced phosphorylation of IkBalpha.17910942
NOS2nitric oxide synthase 2, inducible4843Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----OA inhibited the iNOS and COX-2 mRNA. Raw 264.7 cells were induced with LPS in the presence of various concentration.17910942

 






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