NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Oleandrin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Cervix AdenocarcinomaHeLa----Oleandrin blocked tumor necrosis factor (TNF)-induced activation of NF-kB in a concentration- and time-dependent manner.The TNF-induced NF-kB activation cascade involving TNF receptor 1/TNF receptor-associated death domain/TNF receptor-associated factor 2/NF-kB-inducing kinase/IkBa kinase was interrupted at the TNF receptor-associated factor 2 and NF-kB-inducing kinase sites by oleandrin, thus suppressing NF-kB reporter gene expression.10919658
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790LeukemiaU-937----Oleandrin blocked tumor necrosis factor (TNF)-induced activation of NF-kB in a concentration- and time-dependent manner.The TNF-induced NF-kB activation cascade involving TNF receptor 1/TNF receptor-associated death domain/TNF receptor-associated factor 2/NF-kB-inducing kinase/IkBa kinase was interrupted at the TNF receptor-associated factor 2 and NF-kB-inducing kinase sites by oleandrin, thus suppressing NF-kB reporter gene expression.10919658
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Ovarian CancerCaOV3----Oleandrin blocked tumor necrosis factor (TNF)-induced activation of NF-kB in a concentration- and time-dependent manner.The TNF-induced NF-kB activation cascade involving TNF receptor 1/TNF receptor-associated death domain/TNF receptor-associated factor 2/NF-kB-inducing kinase/IkBa kinase was interrupted at the TNF receptor-associated factor 2 and NF-kB-inducing kinase sites by oleandrin, thus suppressing NF-kB reporter gene expression.10919658
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790T cell leukemiaJurkat T----Oleandrin blocked tumor necrosis factor (TNF)-induced activation of NF-kB in a concentration- and time-dependent manner.The TNF-induced NF-kB activation cascade involving TNF receptor 1/TNF receptor-associated death domain/TNF receptor-associated factor 2/NF-kB-inducing kinase/IkBa kinase was interrupted at the TNF receptor-associated factor 2 and NF-kB-inducing kinase sites by oleandrin, thus suppressing NF-kB reporter gene expression.10919658

 






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